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  5. Tocris Bioscience™ WYE 687 dihydrochloride

Tocris Bioscience™ WYE 687 dihydrochloride
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Product Code. 30001497
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30001505 50 mg 50mg
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Product Code. 30001497 Supplier Tocris Bioscience™ Supplier No. 4282/10

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Description

Potent and selective mTOR inhibitor

Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7 nM). Displays selectivity for mTOR over PI 3-Kα (∽100-fold) and PI 3-Kγ (∽500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1α expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1062161-90-3
Molecular Formula C28H32N8O3

Specifications

Quantity 10 mg
Formula Weight 601.53
Purity >98%
Molecular Weight (g/mol) 528.617
Chemical Name or Material WYE 687 dihydrochloride
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