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Invitrogen™ WWTR1 Recombinant Rabbit Monoclonal Antibody (HL2032)
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Product Code. 30276368
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Quantity:
100 μL
Unit Size:
100µL
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30276368 100 μL 100µL
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Product Code. 30276368 Supplier Invitrogen™ Supplier No. MA556891

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Description

Rabbit Recombinant Monoclonal Antibody

WWTR1 Recombinant Monoclonal Antibody for ICC/IF, Western Blot

WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WWTR1
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone HL2032
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene WWTR1
Gene Accession No. Q9EPK5, Q9GZV5
Gene Alias 2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1
Gene Symbols WWTR1
Host Species Rabbit
Immunogen Recombinant fragment of human TAZ.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25937, 295062, 568008, 97064
Target Species Human, Mouse, Rat, Zebrafish
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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