Invitrogen™ WWC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA558212

Product Code. 15756091

Description

Immunogen sequence: PPCSPLMADP LLAGDAFLNS LEFEDPELSA TLCELSLGNS AQERYRLEEP GTEGKQLGQA VNTAQGC Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 76%.

WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.

Specifications

• Antigen: WWC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: WWC1
• Gene Alias: AA408228; AU017197; BC037006; FLJ10865; FLJ23369; HBeAg-binding protein 3; HBEBP3; HBEBP36; Kiaa0869; KIBRA; Kidney and brain protein; MEMRYQTL; mKIAA0869; PPP1R168; Protein KIBRA; protein phosphatase 1, regulatory subunit 168; protein WWC1; RGD1308329; WW and C2 domain containing 1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1; WWC1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23286
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IX03
• Gene Symbols: WWC1
• Immunogen: Recombinant protein corresponding to Human WWC1. Recombinant protein control fragment (Product #RP-96836).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG