Invitrogen™ WSB1 Monoclonal Antibody (3E10)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA521610

Product Code. 15509022

Description

Peptide Sequence: QGHRTVKLVP WSQCLQNFLL HGTKNVTNSS SLRLPRQNSD GGQKNKPREH IIDCGDIVWS LAFGSSVPEK QSRCVNIEWH RFRFG.

WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein that contains one SOCS box domain and six WD repeats. Expressed as multiple alternatively spliced isoforms, WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2. Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis.

Specifications

• Antigen: WSB1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9Y6I7
• Gene Symbols: WSB1
• Immunogen: WSB1 (AAH21110.1, 53 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA
• Clone: 3E10
• Conjugate: Unconjugated
• Gene: WSB1
• Gene Alias: 1110056B13Rik; 2700038M07Rik; SOCS box-containing WD protein SWiP-1; SWIP1; WD repeat and SOCS box containing 1; WD repeat and SOCS box-containing 1; WD repeat and SOCS box-containing protein 1; WD repeat and SOCS box-containing protein 1-like protein; WD-40-repeat-containing protein with a SOCS box 1; WSB1; WSB-1
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26118
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid