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  5. STEMCELL Technologies Wortmannin

STEMCELL Technologies Wortmannin

Product Code. 17170242
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1 mg
10 mg
Unit Size:
10mg
1mg
Product Code. Quantity unitSize
17170242 10 mg 10mg
17160242 1 mg 1mg
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Product Code. 17170242

Brand: STEMCELL Technologies 73564

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Description

PI3K/AKT pathway inhibitor; Inhibits PI3K and PLKs

  • Wortmannin is a fungal metabolite that covalently binds to and inhibits phosphatidylinositol-3-kinases (PI3K) of class I, II, and III
  • Species-specific differences in the class II PI3Ks determine sensitivity with IC50 = 5, 50, and 450 nM for Drosophila, mouse, and human, respectively (Fruman et al.; Wymann et al.; Okada et al.) Wortmannin also inhibits polo-like kinases (PLK) PLK1 and PLK3 with IC50 = 24 and 49 nM, respectively (Liu et al. 2005; Liu et al. 2007)
  • At high concentrations it can also inhibit other kinases such as mammalian target of rapamycin (mTOR), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), phosphatidylinositol-4-kinase (PI4K), myosin light-chain kinase (MLCK), and mitogen-activated protein kinase (MAPK; Fruman et al.; Meyers & Cantley; Hartley et al.; Brunn et al.; Nakanishi et al.)

Specifications

CAS 19545-26-7
Synonym KY 12420
Quantity 10 mg
Molecular Formula C23H24O8
Purity ≥98%
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