Invitrogen™ Human WNK2, GST Tag Recombinant Protein

Product Code. 15428643

Brand: Invitrogen™ PR8019A

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic

WNK2 is a serine/threonine kinase involved in signal transduction and cellular communication. WNK kinases contain a lysine upstream of the traditional position, within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the alpha and beta phosphoryl groups. The catalytic domains of WNK2, WNK3 and WNK4 are 95% homologous to WNK1. The human WNK1 gene encodes a 2,382 amino acid protein that is primarily expressed in heart, kidney, muscle and distal nephron. The human WNK3 gene encodes a protein that is primarily expressed in brain; the human WNK4 gene encodes a 1,243 amino acid protein that is expressed in kidney. Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption and impaired K+ and H+ excretion.

Specifications

• Accession Number: Q9Y3S1
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50 mM tris with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
• Gene ID (Entrez): 65268
• Molecular Weight (g/mol): 64.9 kDa
• Name: Human WNK2, GST Tag
• Quantity: 100 μg
• Regulatory Status: RUO - research use only
• Gene Alias: 1810073P09Rik; Antigen NY-CO-43; AW122246; ESTM15; Kiaa1760; kinase deficient protein; LOW QUALITY PROTEIN: serine/threonine-protein kinase WNK2; mitogen-activated protein kinase kinase kinase; mKIAA1760; NY-CO-43; P/OKcl0.13; PRKWNK2; protein kinase lysine-deficient 2; Protein kinase with no lysine 2; protein kinase, lysine deficient 2; RGD1307284; SDCCAG43; Serine/threonine-protein kinase WNK2; serologically defined colon cancer antigen 43; WNK lysine deficient protein kinase 2; Wnk2; X83337
• Common Name: WNK2
• KinaseFamily: WNK Kinase Family
• Protein Length: 166-489
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Expression System: Baculovirus
• Form: Liquid