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  5. Tocris Bioscience™ WM 1119

Tocris Bioscience™ WM 1119
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Product Code. 18738676
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18738676

Brand: Tocris Bioscience™ 6692/10

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Description

High affinity KAT6A (MOZ) competitive inhibitor

WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC50 = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.
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Specifications

Chemical Name or Material 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
CAS 2055397-28-7
Quantity 10 mg
Molecular Formula C18H13F2N3O3S
Formula Weight 389.38
Purity 98%
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