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  5. Tocris Bioscience™ WIKI4

Tocris Bioscience™ WIKI4
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Product Code. 18798446
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5 mg
25 mg
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25mg
5mg
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18798446 25 mg 25mg
18737326 5 mg 5mg
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Product Code. 18798446 Supplier Tocris Bioscience™ Supplier No. 4855/25

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Description

Potent tankyrase inhibitor

WIKI4 is an inhibitor of Wnt/β-catenin signaling (EC50 ∼ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ∼15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).

WIKI4 synthesized to Ancillary Material Grade also available.

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Specifications

Chemical Name or Material 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
CAS 838818-26-1
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C29H23N5O3S
Formula Weight Observed MW: 521.59
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