Invitrogen™ WIBG Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA561181

Product Code. 15729001

Description

Immunogen sequence: KEKRRQQQEK GEAEALSRTL DKVSLEETAQ LPSAPQGSRA APTAASDQPD SAATTEKAKK IKNLK Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 78%.

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. [UniProt].

Specifications

• Antigen: WIBG
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PYM1
• Gene Alias: A030010B05Rik; Partner of Y14 and mago; protein wibg homolog; PYM; PYM homolog 1 exon junction complex-associated factor; PYM homolog 1, exon junction complex associated factor; Pym1; RGD1306096; WIBG; within bgcn homolog; within bgcn homolog (Drosophila)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84305
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BRP8
• Gene Symbols: PYM1
• Immunogen: Recombinant protein fragment of Human PYM1 (Product #RP-97825)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG