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Invitrogen™ WHIP Polyclonal Antibody

Product Code. 15774751 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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15774751 100 μL 100µL
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Product Code. 15774751 Supplier Invitrogen™ Supplier No. PA556847

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YQGCHFIGMP ECEVLLAQCV VYFARAPKSI EVYSAYNNVK ARLRNHQGPL PPVPLHLRNA PTRLMKDLGY G Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WHIP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene WRNIP1
Gene Accession No. Q96S55
Gene Alias 4833444L21Rik; ATPase WRNIP1; bA420G6.2; FLJ22526; putative helicase RUVBL; RP11-420G6.2; UniProtKB:Q96S55}; Werner helicasae interacting protein 1; Werner helicase interacting protein 1; Werner helicase-interacting protein 1; Werner syndrome homolog interacting protein; Whip; Wrnip; Wrnip1; wrnip1 {ECO:0000250
Gene Symbols WRNIP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human WHIP. Recombinant protein control fragment (Product #RP-94744).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56897
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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