Invitrogen™ WDFY1/2 Recombinant Rabbit Monoclonal Antibody (HL1989)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA556919

Product Code. 30275577

Description

WDFY1/2 Recombinant Monoclonal Antibody for Western Blot

WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDFY1 positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. WDFY1 Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. WDFY2 acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. WDFY2 positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1.

Specifications

• Antigen: WDFY1/2
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q8IWB7
• Gene Symbols: WDFY1
• Immunogen: Recombinant fragment of human WDFY1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Clone: HL1989
• Conjugate: Unconjugated
• Gene: WDFY1
• Gene Alias: 1700013B03Rik; 1700120F24Rik; FENS1; FENS-1; FYVE domain-containing protein localized to endosomes 1; Jr1; KIAA1435; mKIAA1435; Phosphoinositide-binding protein 1; phosphoinositide-binding protein SR1; WD repeat and FYVE domain containing 1; WD repeat and FYVE domain-containing protein 1; WD40 and FYVE domain containing 1; WD40- and FYVE domain-containing protein 1; WDF1; WDFY1; ZFYVE17; Zinc finger FYVE domain-containing protein 17
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 57590
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid