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  6. Invitrogen™ WAVE1 Recombinant Rabbit Monoclonal Antibody (K01_2K10)

Invitrogen™ WAVE1 Recombinant Rabbit Monoclonal Antibody (K01_2K10)
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Product Code. 30827115
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Product Code. 30827115 Supplier Invitrogen™ Supplier No. MA563925

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MPLVKRNIDP RHLCHTALPR GIKNELECVT NISLANIIRQ LSSLSKYAED IFGELFNEAH SFSFRVNSLQ ERVDRLSVSV TQLDPKEEEL SLQDITMRKA Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%, Pig - 100%, Cynomolgus monkey - 100%.

WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
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Specifications

Antigen WAVE1
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_2K10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 150mM NaCl, 0.05% BSA, 40% glycerol and 0.01% sodium azide; pH 7.4
Gene WASF1
Gene Accession No. Q5BJU7, Q8R5H6, Q92558
Gene Alias AI195380; AI838537; homology of dictyostelium scar 1; KIAA0269; Protein WAVE-1; Scar; SCAR1; Verprolin homology domain-containing protein 1; WAS protein family; WAS protein family member 1; WAS protein family, member 1; WASF1; WASP family 1; WASP family protein member 1; WAVE; WAVE1; WAVE-1; Wiskott-Aldrich syndrome protein family member 1
Gene Symbols WASF1
Host Species Rabbit
Immunogen Recombinant protein of human WAVE 1 (aa 1-100).
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 294568, 83767, 8936
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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