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  5. Tocris Bioscience™ VU 0467485

Tocris Bioscience™ VU 0467485
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Product Code. p-7182961
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18798616

Brand: Tocris Bioscience™ 6932/10

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Description

Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant

VU 0467485 is a potent and selective positive allosteric modulator of M4 receptor; potentiates activity of ACh at M4 (EC50 values are 26.6 and 78.8 nM at rat and human M4 receptors, respectively). Exhibits selectivity for M4 over human and rat M1-3, 5, and a panel of 200 other pharmacological targets. Displays efficacy in a rat model of antipsychotic activity. Orally bioavailable and brain penetrant.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 5-Amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
CAS 1451994-10-7
Quantity 10 mg
Molecular Formula C17H17FN4O2S
Purity 98%
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