VPS8 Monoclonal Antibody (2C8), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA524456

Product Code. 15642285

Description

Peptide Sequence: RITPSQVKMS PSYHQSKGDP TAKKGTSEPV LDPQQIQAFD QLCRLYRGSS RLALLTELSQ NRSSESYRPF SGSQSAPAFN SIFQNENFQL QLIPPPVTED

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). [UniProt]

Specifications

• Antigen: VPS8
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: VPS8
• Gene Alias: AI315068; AU040738; im:7166005; KIAA0804; mKIAA0804; RGD1309443; si:dkey-24b15.1; vacuolar protein sorting 8 homolog; vacuolar protein sorting 8 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 8 homolog; VPS8; VPS8 CORVET complex subunit; VPS8 subunit of CORVET complex; VPS8, CORVET complex subunit; zgc:158695
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 23355
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunocytochemistry, Western Blot
• Clone: 2C8
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q8N3P4
• Gene Symbols: VPS8
• Immunogen: KIAA0804 (NP_001009921, 1329 a.a. ∽ 1428 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b κ