Invitrogen™ Viperin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5117125

Product Code. 17259623

Description

Positive Samples: PC-3, Mouse spleen, Rat lung, Rat spleen, Rat kidney Immunogen sequence: EKINFSGGEP FLQDRGEYLG KLVRFCKVEL RLPSVSIVSN GSLIRERWFQ NYGEYLDILA ISCDSFDEEV NVLIGRGQGK KNHVENLQKL RRWCRDYRVA FKINSVINRF NVEEDMTEQI KALNPVRWKV FQCLLIEGEN CGEDALREAE RFVIGDEEFE RFLERHKEVS CLVPESNQKM KDSYLILDEY MRFLNCRKGR KDPSKSILDV GVEEAIKFSG FDEKMFLKRG GKYIWSKADL KLDW.

Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.

Specifications

• Antigen: Viperin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rsad2
• Gene Alias: 2510004L01Rik; Best5; Bone-expressed sequence tag 5 protein; cig33; cig5; CIG6; cytomegalovirus-induced gene 5 protein; hypothetical protein LOC570456; inflammatory response gene 6 protein; inflammatory response protein 6; IRG6; radical S-adenosyl methionine domain containing 2; radical S-adenosyl methionine domain-containing protein 2; rsad2; rsad2 {ECO:0000250; si:ch211-276e8.2; similar to radical S-adenosyl methionine domain containing 2; UniProtKB:Q8WXG1}; VHSV-induced-like protein; Vig1; Viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible; zgc:112342
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 58185, 65190, 91543
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 3.28 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O70600, Q8CBB9, Q8WXG1
• Gene Symbols: Rsad2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 118-361 of human RSAD2 (NP_5423882).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG