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Vinorelbine ditartrate, Tocris Bioscience™
Selective mitotic microtubule antagonist
Chemical Identifiers
| CAS | 125317-39-7 |
|---|---|
| Molecular Formula | C53H66N4O20 |
| Molecular Weight (g/mol) | 1079.119 |
| InChI Key | CILBMBUYJCWATM-HJBYVSOESA-N |
| Synonym | vinorelbine ditartrate |
| PubChem CID | 124080885 |
| SMILES | CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O |
Description
Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.Chemical Identifiers
| 125317-39-7 | |
| 1079.119 | |
| vinorelbine ditartrate | |
| CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O |
| C53H66N4O20 | |
| CILBMBUYJCWATM-HJBYVSOESA-N | |
| 124080885 |
Specifications
| 125317-39-7 | |
| vinorelbine ditartrate | |
| CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O | |
| 124080885 | |
| >98% |
| C53H66N4O20 | |
| CILBMBUYJCWATM-HJBYVSOESA-N | |
| 1079.119 | |
| 1079.1 | |
| Vinorelbine ditartrate |
Safety and Handling
Recommended Storage : Store at -20°C
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