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Vinculin Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA529688
Code : PN
Additional Details : Weight : 0.01000kg
Description
Recommended positive controls: NT2D1, Mouse brain, HeLa. Predicted reactivity: Human (99%), Mouse (98%), Rat (98%), Pig (98%), Chicken (93%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.Specifications
Vinculin | |
Polyclonal | |
Unconjugated | |
VCL | |
9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; epididymis luminal protein 114; HEL114; metavinculin; meta-vinculin; metavinculin {ECO:0000250; MV; MVCL; RP11-178G16.3; UniProtKB:P18206}; unnamed protein product; Vcl; vcl {ECO:0000250; VIN; vinc; vinc 1; VINC1; Vinculin; vinculin {ECO:0000250 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
22330, 305679, 7414 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
0.21 mg/mL | |
PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
P18206, P85972, Q64727 | |
VCL | |
Recombinant protein fragment corresponding to a region within amino acids 94 and 348 of Human Vinculin | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |