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Vinculin Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA529688

Code : PN

Additional Details : Weight : 0.01000kg

Product Code. 13483917

  • £452.00 / 100µL
Estimated Shipment: 16-05-2024
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Description

Description

Recommended positive controls: NT2D1, Mouse brain, HeLa. Predicted reactivity: Human (99%), Mouse (98%), Rat (98%), Pig (98%), Chicken (93%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
Specifications

Specifications

Vinculin
Polyclonal
Unconjugated
VCL
9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; epididymis luminal protein 114; HEL114; metavinculin; meta-vinculin; metavinculin {ECO:0000250; MV; MVCL; RP11-178G16.3; UniProtKB:P18206}; unnamed protein product; Vcl; vcl {ECO:0000250; VIN; vinc; vinc 1; VINC1; Vinculin; vinculin {ECO:0000250
Rabbit
Antigen affinity chromatography
RUO
22330, 305679, 7414
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
0.21 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
P18206, P85972, Q64727
VCL
Recombinant protein fragment corresponding to a region within amino acids 94 and 348 of Human Vinculin
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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