Thermo Scientific™ Vinculin Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Vinculin Ab-1, Mouse Monoclonal Antibody.

Overview
Brand: Thermo Scientific™

Manufacturer Part Number: MS-1209-R1

1 ML MONOCLONAL ANTIBODY, ANTI-VINCULIN AB-1,host mouse, clone VLN01, isotype IgG, species

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 12689266

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Description and Specification

Specification

Antigen Vinculin Ab-1
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone VLN01
Conjugate Unlabeled
Cross Reactivity Human
Format Prediluted
Formulation Ready-to-use for IHC (UVLP)
Host Species Mouse
Immunogen Semi-purified vinculin
Isotype IgG
Quantity 1mL
Regulatory Status RUO
Research Discipline Cytoskeletal Protein
Type Primary

Vinculin is an attachment protein involved in the indirect binding of intracellular actin filaments to extracellular fibronectin. Vinculin binds to actin capping protein and α actinin, which in turn binds to actin. The binding of fibronectin is also indirect where vinculin binds to talin, which in turn binds to the intracellular domain of the fibronectin receptor which itself is the ligand for fibronectin. Vinculin is widely distributed in tissue and is expressed where smooth muscle actin and fibroblasts attach to the extracellular matrix.

Host Species: Mouse

Clone: VLN01

Isotype: IgG

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Semi-purified vinculin

Molecular Weight: 130kDa (vinculin) and 150kDa (meta-vinculin)

Positive Control: HeLa cells, skin

Cellular Localization: Cell membrane and cytoplasmic Ab-1 is useful for studies of vinculin in platelet activation.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO