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Vimentin Monoclonal Antibody (V9), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA511883
Code : LE
Additional Details : Weight : 0.01000kg
Description
MA5-11883 targets Vimentin in IHC (P) applications and shows reactivity with Bovine, Canine, Chicken, Equine, Feline, Gerbil, Hamster, Human, mouse, Non-human primate, Porcine, Rabbit, and Rat samples. The MA5-11883 immunogen is purified vimentin from pig eye lens.
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.Specifications
Vimentin | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
P02543, P08670, P09654, P20152, P31000, P48616, P48670 | |
Vim | |
Purified vimentin from pig eye lens | |
500 μL | |
Primary | |
Bovine, Porcine, Rabbit, Equine, Canine, Gerbil, Equine, Feline, Mouse, Non-human Primate, Human, Mouse, Non-human Primate | |
Antibody | |
IgG1 κ |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
V9 | |
Unconjugated | |
Vim | |
cb28; class-III intermediate microfilament; CTRCT30; epididymis luminal protein 113; FLJ36605; HEL113; intermediate filament; intermediate filament protein; RP11-124N14.1; similar to vimentin; VIM; VIME; Vimentin; vimentin C-terminus | |
Mouse | |
Protein G | |
RUO | |
100008924, 100056088, 100522394, 100689099, 101091951, 22352, 280955, 420519, 477991, 7431, 81818 | |
4° C | |
Liquid |