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Invitrogen™ NOP56 Polyclonal Antibody
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Product Code. 16397024
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Quantity:
100 μL
Unit Size:
100µL
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16397024 100 μL 100µL
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Product Code. 16397024 Supplier Invitrogen™ Supplier No. PA578329

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Description

Rabbit Polyclonal Antibody

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Chimpanzee (95%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ErbB 4 (Her-4, c-erbB-4, v-erbB-4) is a member of the class I receptor kinase family. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases). ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361. Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOP56
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.54 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Nop56
Gene Accession No. O00567
Gene Alias 2310044F10Rik; 56kDa with KKE/D repeat; hypothetical protein 1195; NOL5A; Nop56; NOP56 ribonucleoprotein; NOP56 ribonucleoprotein homolog; nucleolar protein 56; Nucleolar protein 5A; nucleolar protein 5A (56kDa with KKE/D repeat); SCA36; similar to nucleolar protein 5A (56kDa with KKE/D repeat)
Gene Symbols Nop56
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the C-terminus of human NOL5A. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10528
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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