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ACROBiosystems Biotinylated Mouse FOLR1 Protein, His, Avitag™

Product Code. 15836787
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Quantity:
200 μg
25 μg
Unit Size:
200µg
25µg

Product Code. 15836787

Brand: ACROBiosystems FO1M82E9200UG

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Description

Biotinylated Protein

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 26.9 kDa. The protein migrates as 32-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_032060.2
Molecular Weight (g/mol) 26.9 kDa
Quantity 200 μg
Source Biotinylated Mouse FOLR1, His,Avitag (FO1-M82E9) is expressed from human 293 cells (HEK293). It contains AA Thr 25 - Ser 232 (Accession # P35846-1).
Immunogen Thr 25 - Ser 232
Storage Requirements -20°C
Gene Alias FOLR-1,FBP,FOLR
Common Name FOLR1
Conjugate Precision Avi
Species Mouse
Protein Tag His Tag and Avi Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype MABSol™ Biotin Labeled Proteins
Purity or Quality Grade >95% as determined by SDS-PAGE
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