ACROBiosystems Human CD38 Protein, Fc Tag

Product Code. 15806307

Brand: ACROBiosystems CD8H52551MG

Description

MALS verified

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.5 kDa. The protein migrates as 66-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

• Accession Number: NP_001766.2
• Molecular Weight (g/mol): 56.5 kDa
• Quantity: 1 mg
• Source: Human CD38, Fc Tag (CD8-H5255) is expressed from human 293 cells (HEK293). It contains AA Val 43 - Ile 300 (Accession # P28907-1).
• Immunogen: Val 43 - Ile 300
• Storage Requirements: -20°C
• Gene Alias: CD38,T10,cADPr hydrolase 1
• Common Name: CD38
• Conjugate: Unconjugated
• Species: Human
• Protein Tag: Fc Tag
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Endotoxin Level: Less than 1.0 EU / μg by the LAL method.
• Expression System: HEK293
• Form: Powder
• Protein Subtype: Bio-Markers and CD Antigens
• Purity or Quality Grade: >95% as determined by SDS-PAGE