Invitrogen™ MTA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA530305

Product Code. 13464797

Description

Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (97%), Rat (97%), Zebrafish (88%), Xenopus laevis (92%), Rhesus Monkey (99%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Specifications

• Antigen: MTA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mta2
• Gene Alias: AW550797; DKFZp686F2281; Mata1l1; metastais-associated gene family, member 2; metastasis associated 1 family member 2; metastasis associated 1 family, member 2; metastasis associated 1-like 1; metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; metastasis-associated protein MTA2; mmta2; Mta1l1; MTA1-L1 protein; Mta2; p53 target protein in deacetylase complex; PID
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9219
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.25 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O94776
• Gene Symbols: Mta2
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human MTA2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG