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VEGF Receptor 3, clone: AFL4, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5988-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15227677

  • £151.19 / 500µg


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Description

Description

Description: The AFL4 monoclonal antibody reacts with the mouse VEGF receptor-3, also known as Flt-4. This 195kDa molecule was identified as an endothelial-specific member of the receptor tyrosine kinase (RTK) family. During early embryogenesis all endothelial cells express VEGFR-3, while in the adult tissues, VEGFR-3 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. However, VEGFR-3 expression is induced in the adult tissue upon tumor implementation suggesting an important role for this receptor in the tumor angiogenesis. VEGF-C and VEGF-D bind to and activate VEGFR-3. AFL4 is an antagonist mAb.Applications Reported: The AFL4 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, immunoblotting (WB), and immunohistochemical staining of frozen tissue sections. It has also been reported in blocking of ligand binding. (Please use Functional Grade purified AFL4, cat. 16-5988, in functional assays.).Applications Tested: The AFL4 antibody has been tested by flow cytometric analysis of in vitro differentiated mouse endothelial cells. In brief, mouse ES cells were incubated on collagen IV matrix for 4 days and subsequently stimulated with VEGF under serum free conditions to induce further differentiation. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

VEGF Receptor 3
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P35917
FLT41, PCL, FLT4
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Western Blot
AFL4
Unconjugated
Flt4
Purified
Flt4
IgG2a, kappa
500μg
Store at 2-8°C.
Primary
14257
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