VEGF Receptor 3 Rat anti-Mouse, Clone: AFL4, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5988-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15227677

Quantity Price
1 £ 146.13 / 500µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Antigen VEGF Receptor 3
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL
Clone AFL4
Format Purified
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Quantity 500μg
Monoclonal or Polyclonal Monoclonal
Gene Alias VEGFR3, VEGF R3, VEGF receptor 3, Flt-4, Flt4, vascular endothelial growth factor receptor 3
Host Species Rat
Primary or Secondary Primary
Conjugate Unlabeled
Isotype IgG2a
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.

The AFL4 monoclonal antibody reacts with the mouse VEGF receptor-3, also known as Flt-4. This 195kDa molecule was identified as an endothelial-specific member of the receptor tyrosine kinase (RTK) family. During early embryogenesis all endothelial cells express VEGFR-3, while in the adult tissues, VEGFR-3 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. However, VEGFR-3 expression is induced in the adult tissue upon tumor implementation suggesting an important role for this receptor in the tumor angiogenesis. VEGF-C and VEGF-D bind to and activate VEGFR-3. AFL4 is an antagonist mAb.