VEGF Receptor 1 (Flt1) Rat anti-Human, Clone: 7A6, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5936-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15257607

Quantity Price
1 £ 54.42 / 25µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Quantity 25μg
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Format Purified
Applications Western Blotting
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Gene Alias VEGF-R1, Flt-1, FMS-like tyrosine kinase 1, vascular endothelial growth factor receptor
Isotype IgG2a
Primary or Secondary Primary
Clone 7A6
Antigen VEGF Receptor 1 (Flt1)
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Concentration 0.5mg/mL

This 7A6 monoclonal antibody recognizes human VEGFR1 (vascular endothelial growth factor receptor 1, fms-like tyrosine kinase 1, FLT1). It is directed against the extracellular domain and can recognize both membrane-bound and soluble forms of VEGFR1, with approximate molecular weights of 180kDa and 90 kDa, respectively. Mice lacking expression of VEGFR1 have disorganized vasculature and die in utero, however angiogenesis does not require the tyrosine kinase activity of VEGFR1 as expression of a membrane-bound form lacking the tyrosine kinase domain allows normal development. Although fertile and viable, mice lacking the tyrosine kinase domain of VEGFR1 do have a defect in the migration of macrophages. The soluble form of VEGFR1 can be detected in the serum of normal patients, and elevated levels of soluble VEGFR1 in pregnant women is associated with preeclampsia. Several tumor cell lines have been reported to express membrane-bound VEGFR1, including malignancies of hematopoietic origin.