Invitrogen™ VAV1 Monoclonal Antibody (GT557)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA531488

Product Code. 16384924

Description

Keep as concentrated solution. Predicted reactivity: Mouse (92%), Rat (92%), Pig (96%), Bovine (96%). Positive Control: Jurkat, NCI-H929. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Specifications

• Antigen: VAV1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P15498, P27870
• Gene Symbols: VAV1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: GT557
• Conjugate: Unconjugated
• Gene: VAV1
• Gene Alias: oncogene vav; p95; p95vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav guanine nucleotide exchange factor 1; vav oncogene; vav proto-oncogene; VAV1; vav-T
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22324, 7409
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid