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  5. Tocris Bioscience™ Vatalanib succinate

Tocris Bioscience™ Vatalanib succinate
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Product Code. 18780919
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18780919

Brand: Tocris Bioscience™ 5680/50

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Description

Potent VEGFR inhibitor; also aromatase inhibitor

Vatalanib succinate is a potent VEGFR inhibitor (IC50 values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC50 = 50 nM). Orally available.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate
CAS 212142-18-2
Synonym CGP 79787D, PTK787/ZK222584
Quantity 50 mg
Target VEGF Receptor Inhibitors
Molecular Formula C20H15ClN4.C4H6O4
Formula Weight 464.9
Purity >99%
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