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Invitrogen™ VANGL2 Polyclonal Antibody
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Product Code. 13287138
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Quantity:
100 μg
Unit Size:
100µg
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13287138 100 μg 100µg
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Product Code. 13287138 Supplier Invitrogen™ Supplier No. PA523207

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Description

Rabbit Polyclonal Antibody

Sequence homology: Chimpanzee (100%), Opossum/Equine (93%), Chicken/Xenopus (73%).

Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VANGL2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene Vangl2
Gene Accession No. P84889, Q91ZD4, Q9ULK5
Gene Alias C530001F03Rik; KIAA1215; loop tail associated protein; loop-tail; Loop-tail protein 1; loop-tail protein 1 homolog; Loop-tail-associated protein; Lp; LPP1; Ltap; MGC119403; MGC119404; RGD:1309442}; ska>m17Jus>; ska17; STB1; stbm; STBM1; strabismus; Strabismus 1; van Gogh-like protein 2; vang; vang (van gogh)-like 2; Vang1l2; VANGL planar cell polarity protein 2; Vangl2; vangl2 {ECO:0000312; vang-like 2 (van gogh, Drosophila); vang-like protein 2
Gene Symbols Vangl2
Host Species Rabbit
Immunogen A portion of amino acids 300-350 of human Van Gogh like-2 protein.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 289229, 520544, 57216, 610037, 93840
Target Species Human, Mouse, Rat, Canine, Monkey, Bovine
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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