Vancomycin Hydrochloride, MP Biomedicals™

Indicated for the treatment of serious infections caused by methicillin-resistant strains. Vancomycin Hydrochloride, MP Biomedicals is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is

Brand:  MP Biomedicals 02195540.1

Product Code. 11455492

Description

Indicated for the treatment of serious infections caused by methicillin-resistant strains. Vancomycin Hydrochloride, MP Biomedicals is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is

Vancomycin, from Streptomyces orientalis, block bacterial cell wall biosynthesis by inhibiting incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. It also alters bacterial-cell-membrane permeability and RNA synthesis. It is widely studied in cancer patients.

Vancomycin is effective against Gram-positive bacteria. It is only indicated for the treatment of serious, life-threatening infections that are unresponsive to other less-toxic antibiotics. In particular, it is used to treat infections caused by susceptible strains of methicillin-resistant (β-lactam-resistant) staphylococci bacteria. It should not be used to treat methicillin-sensitive Staphylococcus aureus, because it is inferior to penicillins such as nafcillin.

Specifications

• Physical Form: Powder
• pH: 2.5 to 4.5 (5% aq. soln.)
• Molecular Formula: C66H257Cl2N9O24
• Solubility Information: Soluble in water (>100 mg/mL). Moderately soluble in dilute methanol. Insoluble in acetone, alcohols, and ether.
• SMILES: C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.CC(C1=CC(=C(C=C1)OC2CC(C(C(O2)CO)O)O)OC3=CC=CC=C3)NC(=O)C.C(=O)O.N.N.N.N.N.N.N.N.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.Cl.Cl
• Molecular Weight (g/mol): 1632.721
• Formula Weight: 1485.7

• CAS: 123409-00-7
• Source: Streptomyces orientalis
• Potency: ca. 1000μg/mg
• InChI Key: ARNOCQCQWLXLRG-UHFFFAOYSA-N
• IUPAC Name: azane;N-[1-[4-[4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-phenoxyphenyl]ethyl]acetamide;formic acid;methane;pentadecahydrate;dihydrochloride
• PubChem CID: 44134997
• Quantity: 100 mg

Safety and Handling

Product Identifier

• Vancomycin Hydrochloride

Signal Word

• Warning

Hazard Category

• Skin sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.

Precautionary Statement

• P101-If medical advice is needed, have product container or label at hand.
• P102-Keep out of reach of children.
• P103-Read label before use.
• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P321-Specific treatment (see on this label).
• P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.