Invitrogen™ VAMP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA588582

Product Code. 16566781

Description

Immunogen sequence: MSATAATAPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG; Positive Samples: 22Rv1, Mouse brain, Mouse lung, Rat brain; Cellular Location: Cell junction, Cell membrane, Cytoplasmic vesicle, Single-pass type IV membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome.

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.

Specifications

• Antigen: VAMP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VAMP2
• Gene Alias: RATVAMPB; RATVAMPIR; SYB; SYB2; Syb-2; sybII; Synaptobrevin; synaptobrevin 2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin II; synaptobrevin-2; vamp; Vamp2; VAMP-2; vesicle associated membrane protein 2; vesicle-associated membrane 2; Vesicle-associated membrane protein (synaptobrevin 2); vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22318, 24803, 6844
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P63027, P63044, P63045
• Gene Symbols: VAMP2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VAMP2 (NP_0550472).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG