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TCR V beta 5.1/5.2 Mouse anti-Mouse, APC, Clone: MR9-4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5796-80

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15598126

  • £91.50 / 25µg

Estimated Shipment date
from Supplier 30-03-2020

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Description

Description

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications

Specifications

TCR V beta 5.1/5.2
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
TCRV beta 5.1; TCRV beta 5.2; TCRV beta5.1; TCRV beta5.2; TCR V beta5.1; TCR V beta5.2; Vb5.1; Vbeta5.1; Vb5.2; Vbeta5.2
IgG1, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
Mouse
Flow Cytometry
MR9-4
APC
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
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