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V alpha 24 J alpha 18 TCR Mouse anti-Human, PerCP-eFluor 710, Clone: 6B11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-5806-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15579276

  • £227.17 / 100 tests


EU Stock 2
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Disclaimers:

For Research Use Only.


Description

Description

The 6B11 monoclonal antibody reacts with an epitope of the CDR3 formed by the germ-line configuration of the V alpha 24 and J alpha 18 of the TCR alpha locus, which results in the expression of an invariant T-cell receptor (TCR) expressed by invariant NK T cells (iNKT). This TCR is homologous to the murine V alpha 14 J alpha 18. This TCR alpha chain pairs with a restricted set of rearranged TCR beta chains, with V beta 11 being the most prominent in humans. NK T cells are restricted by the CD1d molecule and are activated by a CD1d-presented glycolipid ligand, which results in the rapid production of IL-4, IL-13 and IFN gamma. Although iNKT cells have NK-like cytolytic activity, they are considered regulators of immune responses because they rapidly produce large amounts of both Th1 and Th2 cytokines in autoimmune disease, infectious disease, and cancer. The number of iNKT cells present in peripheral blood of normal humans shows considerable variability ranging from 0.01-1% of total peripheral T cells.
Specifications

Specifications

V alpha 24 J alpha 18 TCR
6B11
PerCP-eFluor 710
Conjugated
IgG1
RUO
Primary
Human
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
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