Invitrogen™ UTRN Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5143876

Product Code. 17931051

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human Sw620 whole cell, human Caco-2 whole cell, human THP-1 whole cell, mouse lung tissue. ICC/IF: CACO-2 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The UTRN gene encodes the utrophin protein, which is closely related to dystrophin in structure and function, playing a crucial role in maintaining the integrity of muscle fiber membranes. Located on chromosome 6, utrophin is expressed widely in fetal tissues but is replaced by dystrophin in mature muscle fibers; however, it remains present in adult tissues such as the neuromuscular junction and blood vessels. Utrophin's primary role is to stabilize the cytoskeleton and membrane linkages, forming part of the protein complex responsible for structural support in muscle cells. This protein has garnered significant attention in the context of muscular dystrophies, particularly Duchenne Muscular Dystrophy (DMD), where utrophin upregulation is considered a potential therapeutic strategy to compensate for the lack of functional dystrophin. It helps to ameliorate muscle pathology by mimicking the stabilizing effects of dystrophin, thus preserving muscle function and reducing damage. Research on enhancing utrophin expression is ongoing, aiming to provide an effective treatment modality for DMD and other dystrophin-associated disorders.

Specifications

• Antigen: UTRN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UTRN
• Gene Alias: DMDL; DRP; DRP1; DRP-1; Dystrophin-related protein 1; UTRN; Utrophin
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22288, 7402
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: P46939
• Gene Symbols: UTRN
• Immunogen: E.coli-derived human Utrophin/UTRN recombinant protein (Position: L1211-K2294).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG