Invitrogen™ USP6 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA5142888

Product Code. 17808552

Description

Additional Information: This antibody is expected NOT to cross react to USP32 or to the TBC1D3 proteins. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000. Preliminary analysis showed no signal in Western Blot.

USP6 is a deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. It catalyzes its own deubiquitination. In vitro, isoform2, but not isoform3, shows deubiquitinating activity. USP6 promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. It is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.

Specifications

• Antigen: USP6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: USP6
• Gene Alias: Deubiquitinating enzyme 6; HRP1; hyperpolymorphic gene 1; proto-oncogene TRE-2; TBC1D3 and USP32 fusion; TRE17; TRE2; Tre-2; TRESMCR; Ubiquitin carboxyl-terminal hydrolase 6; ubiquitin specific peptidase 6; ubiquitin specific peptidase 6 (Tre-2 oncogene); ubiquitin specific protease 6 (Tre-2 oncogene); ubiquitin thioesterase 6; ubiquitin thiolesterase 6; ubiquitin-specific protease USP6; ubiquitin-specific-processing protease 6; USP6; USP6-short
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 9098
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P35125
• Gene Symbols: USP6
• Immunogen: Peptide with sequence C-HHIDLDVRTTLRNH.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG