USP5 Mouse anti-Human, Clone: 3F12C10, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66213-1-IG-20UL

Product Code. 16827885

Description

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Specifications

• Antigen: USP5
• Classification: Monoclonal
• Concentration: 0.91 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P45974
• Gene Symbols: USP5
• Immunogen: USP5 Fusion Protein Ag7575
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 3F12C10
• Conjugate: Unconjugated
• Gene: USP5
• Gene Alias: Deubiquitinating enzyme 5, Isopeptidase T, ISOT, Ubiquitin thiolesterase 5, USP5
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 8078
• Content And Storage: -20°C
• Form: Liquid