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USP28 Polyclonal Antibody, Invitrogen™

Goat Polyclonal Antibody

Brand:  Invitrogen PA5142383

Additional Details : Weight : 0.01000kg

Product Code. 17836922

  • £370.00 / 100µL
Estimated Shipment: 06-08-2024
to see stock.

Description

Description

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Specifications

Specifications

USP28
Polyclonal
Unconjugated
USP28
9830148O20Rik; AU022237; Deubiquitinating enzyme 28; Kiaa1515; mKIAA1515; ubiquitin carboxyl-terminal hydrolase 28; ubiquitin carboxyl-terminal hydrolase 28 variant 1; ubiquitin specific peptidase 28; ubiquitin specific protease 28; ubiquitin thioesterase 28; ubiquitin thiolesterase 28; ubiquitin-specific-processing protease 28; Usp28
Goat
Ammonium sulfate precipitation
RUO
57646
-20° C, Avoid Freeze/Thaw Cycles
IgG
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Q96RU2
USP28
Peptide with sequence C-SVELKHYIQEDN.
100 μg
Primary
Human
Liquid
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