Invitrogen™ USP11 Recombinant Rabbit Monoclonal Antibody (8I1K10)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA537919

Product Code. 17276793

Description

Positive Samples: HeLa, 293T, Jurkat, Mouse brain, Rat testis, Rat brain Immunogen sequence: WYCPSCKQHQ LATKKLDLWM LPEILIIHLK RFSYTKFSRE KLDTLVEFPI RDLDFSEFVI QPQNESNPEL YKYDLIAVSN HYGGMRDGHY TTFACNKDSG Q.

USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression.

Specifications

• Antigen: USP11
• Classification: Recombinant Monoclonal
• Concentration: 2.35 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P51784, Q5D006, Q99K46
• Gene Symbols: USP11
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 800-900 of human USP11 (P51784).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 8I1K10
• Conjugate: Unconjugated
• Gene: USP11
• Gene Alias: 6230415D12Rik; deubiquitinating enzyme 11; mKIAA4085; RP4-659F15.2; Ubiquitin carboxyl-terminal hydrolase 11; ubiquitin carboxyl-terminal hydrolase, X-linked; ubiquitin specific peptidase 11; ubiquitin specific protease 11; ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; ubiquitin-specific-processing protease 11; UHX1; USP11
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 236733, 408217, 8237
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid