Invitrogen™ USP11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557994

Product Code. 15785881

Description

Immunogen sequence: VEPQEDTRLW AKNSEGSLDR LYDTHITVLD AALETGQLII METRKKDGTW PSAQLHVMNN NMSEEDEDFK GQPGICGLTN LGNT Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.

USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression.

Specifications

• Antigen: USP11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: USP11
• Gene Alias: 6230415D12Rik; deubiquitinating enzyme 11; mKIAA4085; RP4-659F15.2; Ubiquitin carboxyl-terminal hydrolase 11; ubiquitin carboxyl-terminal hydrolase, X-linked; ubiquitin specific peptidase 11; ubiquitin specific protease 11; ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; ubiquitin-specific-processing protease 11; UHX1; USP11
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 236733, 8237
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP Assay, Immunohistochemistry (Paraffin)
• Concentration: 0.20 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P51784, Q99K46
• Gene Symbols: USP11
• Immunogen: Recombinant protein corresponding to Human USP11. Recombinant protein control fragment (Product #RP-95437).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG