Invitrogen™ Urotensin II Receptor Monoclonal Antibody (443707)

Rat Monoclonal Antibody

Brand:  Invitrogen™ MA562011

Product Code. 30534109

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

The Urotensin-II receptor has been reported to be expressed at high levels in the heart and pancreas and also in artery and smooth muscle. Low transcript levels have been identified in brain, particularly in thalamus, and superior occipital gyrus. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: Urotensin II Receptor
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with trehalose and no preservative
• Gene Accession No.: Q8VIH9
• Gene Symbols: UTS2R
• Immunogen: Mouse Urotensin-II R synthetic peptide.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry
• Clone: 443707
• Conjugate: Unconjugated
• Gene: UTS2R
• Gene Alias: G protein-coupled receptor 14; GPR14; G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; putative G protein-coupled receptor (SENR); Senr; Uiir; Uii-r; Uii-r1a; UII-receptor; UR2R; UR-2-R; UR-II-R; urotensin 2 receptor; urotensin II receptor; Urotensin-2 receptor; UT-II; UTIIR; UTR; UTR2; Uts2r
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 217369
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized