UPF2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA528629

Product Code. 13442747

Description

Recommended positive controls: mouse brain. Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.

Specifications

• Antigen: UPF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UPF2
• Gene Alias: HUPF2; KIAA1408; Nonsense mRNA reducing factor 2; regulator of nonsense transcripts 2; RENT2; smg-3; smg-3 homolog, nonsense mediated mRNA decay factor; UPF2; UPF2 regulator of nonsense transcripts homolog (yeast); up-frameshift suppressor 2 homolog; yeast Upf2p homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26019, 326622
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9HAU5
• Gene Symbols: UPF2
• Immunogen: Synthetic peptide corresponding to a region within amino acids 1200 and 1272 of Human Rent2
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG