uPAR Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16856573	Proteintech 10286-1-AP-20UL	20 μL
16846573	Proteintech 10286-1-AP-150UL	150 μL

Description

The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.

Specifications

• Antigen: uPAR
• Applications: Western Blot, Flow Cytometry, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Human
• Gene Accession No.: P35456, Q03405
• Gene ID (Entrez): 18793, 5329
• Immunogen: uPAR Fusion Protein Ag0187
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: PLAUR

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CD87, MO3, PLAUR, U PAR, UPAR, URKR
• Gene Symbols: Plaur
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody