Invitrogen™ UNG Recombinant Rabbit Monoclonal Antibody (24GB2530)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30275304	Invitrogen™ MA557832	100 μL

Description

UNG Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow

The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB. The cDNAs for UNG1 and UNG2 are of similar size (2061 and 2058 bp, respectively) and as a result the corresponding mRNAs are not resolved as two species in gel electrophoresis. Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence that is not necessary for catalytic activity. A major role of the UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues. The level and expression pattern of UNG1 and UNG2 differs between cell and tissue type. Additionally, the expression of UNG is cell cycle regulated. The expression and activity of UNG has been found in general to be higher in proliferating as compared to nonproliferating tissues and cells. UNG1 is a 304 amino acid protein. UNG2 is a 313 amino acid protein.

Specifications

• Antigen: UNG
• Concentration: 0.71 mg/mL
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P13051
• Gene ID (Entrez): 7374
• Immunogen: A synthesized peptide derived from human UNG (aa 20-88).
• Product Type: Antibody

• Clone: 24GB2530
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: Ung
• Gene Alias: DGU; DKFZp781L1143; HIGM4; HIGM5; UDG; UNG; Ung1; UNG15; UNG2; unga; uracil DNA glycosylase; uracil DNA glycosylase a; uracil-DNA glycosylase; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; uracil-DNA glycosylase isoform UNG1; uracil-DNA glycosylase isoform UNG2; uracil-DNA glycosylase nuclear isoform; zgc:56102
• Gene Symbols: Ung
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography