Invitrogen™ UGT1A4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA590760

Product Code. 16507991

Description

Immunogen sequence: MARGLQVPLP RLATGLLLLL SVQPWAESGK VLVVPTDGSP WLSMREALRE LHARGHQAVV LTPEVNMHIK EEKFFTLTAY AVPWTQKEFD RVTLGYTQGF; Positive Samples: Mouse liver, Mouse stomach, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.

Specifications

• Antigen: UGT1A4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UGT1A4
• Gene Alias: bilirubin UDP-glucuronosyltransferase isozyme 2; bilirubin-specific UDPGT isozyme 2; GNT1; hUG-BR2; UDP glucuronosyltransferase 1 family, polypeptide A4; UDP glucuronosyltransferase family 1 member A4; UDP glycosyltransferase 1 family, polypeptide A4; UDP-glucuronosyltransferase 1 family polypeptide A4s; UDP-glucuronosyltransferase 1-4; UDP-glucuronosyltransferase 1A4; UDP-glucuronosyltransferase 1-D; UDPGT; UDPGT 1-4; UGT1; UGT1.4; UGT1-04; UGT1A4; UGT1A4S; UGT1D; UGT-1D
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54657
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P22310
• Gene Symbols: UGT1A4
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UGT1A4 (NP_0090511).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG