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Invitrogen™ UGT1A4 Polyclonal Antibody
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Product Code. 16507991
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Quantity:
100 μL
Unit Size:
100µL
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16507991 100 μL 100µL
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Product Code. 16507991 Supplier Invitrogen™ Supplier No. PA590760

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MARGLQVPLP RLATGLLLLL SVQPWAESGK VLVVPTDGSP WLSMREALRE LHARGHQAVV LTPEVNMHIK EEKFFTLTAY AVPWTQKEFD RVTLGYTQGF; Positive Samples: Mouse liver, Mouse stomach, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UGT1A4
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.42 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene UGT1A4
Gene Accession No. P22310
Gene Alias bilirubin UDP-glucuronosyltransferase isozyme 2; bilirubin-specific UDPGT isozyme 2; GNT1; hUG-BR2; UDP glucuronosyltransferase 1 family, polypeptide A4; UDP glucuronosyltransferase family 1 member A4; UDP glycosyltransferase 1 family, polypeptide A4; UDP-glucuronosyltransferase 1 family polypeptide A4s; UDP-glucuronosyltransferase 1-4; UDP-glucuronosyltransferase 1A4; UDP-glucuronosyltransferase 1-D; UDPGT; UDPGT 1-4; UGT1; UGT1.4; UGT1-04; UGT1A4; UGT1A4S; UGT1D; UGT-1D
Gene Symbols UGT1A4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UGT1A4 (NP_0090511).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54657
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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