Invitrogen™ UCN3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA568437

Product Code. 15826853

Description

UCN3 Polyclonal Antibody for Western Blot, IHC (P)

Urocortin 3 (UCN3) is a member of the corticotropin-releasing factor (CRF) family, encoded by the UCN3 gene, and is primarily involved in stress response and energy balance regulation. UCN3 is predominantly expressed in the hypothalamus and certain peripheral tissues, such as pancreatic islets, where it plays significant roles in modulating anxiety-related behaviors and metabolism. This neuropeptide functions by binding to CRF2 receptors, exerting effects on glucose metabolism and insulin secretion. UCN3 has been implicated in protecting the heart from ischemic damage and modulating the cardiovascular system's response to stress, highlighting its potential in treating cardiac disorders. Additionally, it influences nutrient partitioning and energy homeostasis, with expression levels affected by nutritional status. Research indicates that UCN3 deficiency may lead to impaired glucose tolerance and altered energy expenditure, demonstrating its importance in metabolic health. Furthermore, UCN3 has been associated with the regulation of neuroendocrine signaling pathways, providing insights into therapeutic strategies for metabolic and stress-related disorders.

Specifications

• Antigen: UCN3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UCN3
• Gene Alias: prepro-urocortin 3; RGD1562213; SCP; SPC; Stresscopin; ucn III; Ucn3; UCNIII; urocortin 3; urocortin 3 (stresscopin); Urocortin II; Urocortin III; Urocortin-3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114131
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.6 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q969E3
• Gene Symbols: UCN3
• Immunogen: Synthesized peptide derived from human UCN3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG