Invitrogen™ UCMA Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA561295

Product Code. 15779111

Description

Immunogen sequence: YYEEQRNEFE NFVEEQNDEQ EERSREAVEQ WRQWHYDGLH PSYLYNRHHT Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.

UCMA is a gene that encodes for a protein that is specific to chondrocytes and highly charged. This protein is expressed abundantly in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the protein has been associated with osteoarthritis in humans. Alternative splicing of the gene results in multiple transcript variants that encode different isoforms. UCMA is also associated with diseases such as Osteoarthritis and Poland Syndrome.

Specifications

• Antigen: UCMA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UCMA
• Gene Alias: 1110017I16Rik; AW121955; C10orf49; Gla-rich protein; GRP; GRP/UCMA; RGD1308977; Ucma; ucma {ECO:0000250; Ucma-C; UniProtKB:Q14BU0}; Unique cartilage matrix-associated protein; unique cartilage matrix-associated protein {ECO:0000250; Unique cartilage matrix-associated protein C-terminal fragment; upper zone of growth plate and cartilage matrix associated; upper zone of growth plate and cartilage matrix associated protein
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 221044
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8WVF2
• Gene Symbols: UCMA
• Immunogen: Recombinant protein corresponding to Human UCMA. Recombinant protein control fragment (Product #RP-100763).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG