Invitrogen™ UCMA Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA520768

Product Code. 12858912

Description

A suggested positive control is SW1353 cell lysate. PA5-20768 can be used with blocking peptide PEP-0882.

UCMA is a gene that encodes for a protein that is specific to chondrocytes and highly charged. This protein is expressed abundantly in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the protein has been associated with osteoarthritis in humans. Alternative splicing of the gene results in multiple transcript variants that encode different isoforms. UCMA is also associated with diseases such as Osteoarthritis and Poland Syndrome.

Specifications

• Antigen: UCMA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UCMA
• Gene Alias: 1110017I16Rik; AW121955; C10orf49; Gla-rich protein; GRP; GRP/UCMA; RGD1308977; Ucma; ucma {ECO:0000250; Ucma-C; UniProtKB:Q14BU0}; Unique cartilage matrix-associated protein; unique cartilage matrix-associated protein {ECO:0000250; Unique cartilage matrix-associated protein C-terminal fragment; upper zone of growth plate and cartilage matrix associated; upper zone of growth plate and cartilage matrix associated protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 221044, 68527
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q14BU0, Q8WVF2
• Gene Symbols: UCMA
• Immunogen: A 16 amino acid peptide near the carboxy terminus of human UCMA.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG