Invitrogen™ UBR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA555715

Product Code. 15783631

Description

Immunogen sequence: QPNLTQWIRT ISQQIKALQF LRKEESTPNN ASTKNSENVD ELQLPEGFRP DFRPKIPYSE SIKEMLTTFG TATYKVGLKV HPN Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 65%.

The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, including Eps15, LNX1 and Notch 1. NumbL (NUMB-like protein), also known as Numb-R, NBL, CAG3A, CTG3a, NUMBLIKE or TNRC23, is a 609 amino acid cytoplasmic protein that, like NUMB, is thought to play a role in cell fate. Expressed at high levels in developing brain tissue, NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, possibly associating with Eps15 and Notch 1. In mice, deletion of the NumbL gene is associated with early embryonic death, suggesting an essential role for NumbL in early development.

Specifications

• Antigen: UBR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBR2
• Gene Alias: 9930021A08Rik; AI462103; AW540746; bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3; E130209G04Rik; E3 ubiquitin-protein ligase UBR2; Kiaa0349; mKIAA0349; N-recognin-2; RING-type E3 ubiquitin transferase UBR2; si:ch211-239i4.2; ubiquitin ligase E3 alpha-II; ubiquitin protein ligase E3 component n-recognin 2; ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II; Ubr2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23304
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IWV8
• Gene Symbols: UBR2
• Immunogen: Recombinant protein corresponding to Human UBR2. Recombinant protein control fragment (Product #RP-94602).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG