Invitrogen™ UBAP2L Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5106766

Product Code. 16633205

Description

Antibody detects endogenous levels of total UBAP2L.

NICE4, also known as UBAP2L (Ubiquitin-associated protein 2-like) orKIAA0144, is a 1,087 amino acid protein that is ubiquitously expressed. Phosphorylated upon DNA damage, NICE4 contains one UBA domain and is expressed as 4 isoforms produced by alternative splicing events. The gene that encodes NICE4 maps to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Specifications

• Antigen: UBAP2L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBAP2L
• Gene Alias: 3110083O19Rik; 4932431F02Rik; A430103N23Rik; Atp8b2; Atpase, class I, type 8B, member 2; C77168; EP1; KIAA0144; mKIAA0144; NICE4; NICE-4; Nice-4 protein homolog; Protein NICE-4; Ubap2l; ubiquitin associated protein 2 like; ubiquitin associated protein 2-like; ubiquitin-associated protein 2-like
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361984, 74383, 9898
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14157, Q80X50
• Gene Symbols: UBAP2L
• Immunogen: A synthesized peptide derived from human UBAP2L(Accession Q14157), corresponding to amino acid residues S569-N619.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG