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STEMCELL Technologies U-0126

Product Code. 17190232
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Quantity:
1 mg
10 mg
Unit Size:
10mg
1mg
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Product Code. 17190232

Brand: STEMCELL Technologies 73522

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This item is not returnable. View return policy

Description

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

  • U-0126 is a selective, non-ATP competitive inhibitor of mitogen activated protein kinase kinase (MEK), inhibiting MEK1 and MEK2 with IC50 values of 72 nM and 58 nM, respectively (Favata et al.; Scherle et al.) It shows little or no inhibition at micromolar levels of other kinases such as ERK, protein kinase C (PKC), c-Jun N-terminal kinases (JNK), other MAP kinase kinases (MKK3, MKK4, MKK6), cyclin-dependent kinases (CDK2, CDK4), ABL, and RAF (Favata et al.) 1998)
  • U-0126 also antagonizes AP-1 transcription and selectively inhibits promoters containing AP-1 response elements (Favata et al.)

Specifications

CAS 109511-58-2
Quantity 1 mg
Molecular Formula C18H16N6S2
Purity ≥98%
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